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by | Dec 3, 2015 | 1 comment

Well the distractions of ‘Black Friday’ and its newer, perhaps less brash cousin ‘Cyber Monday’ are over and yesterday there were 11 phone calls to the office.  Three were concerning sourcing alternative and extra B12 injections (always a tricky subject) and three were about patients having their injections stopped.  I usually take at least one call per day relating to injections being stopped but three in one day is a record I think.  The other calls were about not being diagnosed, frustration at doctors not reading the summary of the new guidelines and general animosity towards the medical profession because of this.

I will go into the office later today (Thursday) but the office will be closed on Friday as I have a  interesting meeting planned with a Professor at Oxford who has been making remarkable discoveries about the MTHFR gene (MMACHC-MMADHC heterodimerization forms the essential trafficking chaperone delivering cobalamin to client enzymes – if you must know) and as this could be one reason why some patients ether need more frequent treatment or do not respond to treatment as they should then it’s obviously of interest.

Now why, you may think, and I going to Oxford to discuss Professor Yeo’s work when I am not a scientist.  Good question – I’m certainly not going to be able to comment on the work itself but, and it’s a big but, what I can do is raise awareness of the problems in getting adequate and effective treatment.  And this in turn will hopefully be the beginning of a study that will show how scientific knowledge in this area could impact on patients’ lives and have a practical outcome.  Fingers crossed.


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1 Comment

  1. Martin Harvey

    Still digesting the vast subject of B12 deficiency pathologies that Martyn introduced me to last sunday. As part of that, and very relevant to Podiatric Medicine, I noted the phrase in a research article that I was perusing : “Onset is often with a sensation of cold, numbness, or tightness in the tips of the toes and then in the fingertips, rarely with lancinating pains. Simultaneous involvement of arms and legs is uncommon, and onset in the arms is even rarer”. How often are we missing this as a cause of ‘neuropathy’ in podiatry? Quite a lot I suspect. The research article is here:


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